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Question:

How should a prescription be filled when the prescriber indicates dispense as written on the prescription?

A with the brand name drug
Explaination

When dispense as written is indicated, the prescriber wants the prescription filled exactly as written, with the brand name drug. Dispense as written only comes into play in real-world applications when the prescriber wants only a brand name drug. The point of dispense as written is to stop the automatic substitution to a generic drug, so a prescription would not be written "dispense as written" for a generic drug.