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Question:

What is a therapeutic substitution?

A substitution of a drug for another drug that is chemically different but exerts the same clinical effect

explanation

A therapeutic substitution may be made for a brand or generic drug. The clinical effect must be the same for the substitution to be considered therapeutic.

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What is the purpose of a group purchasing organization for a hospital pharmacy?

Negotiate prices with drug manufacturers

Group purchasing organizations (GPOs) negotiate prices with the drug manufacturers for their members.

If a pharmacy stocks hazardous chemicals, what must be provide to the purchaser?

Safety Data Sheets

OSHA requires an SDS sheet be provided to a purchaser of hazardous chemicals.

During a drug recall, how can a pharmacy know what drug stock needs to be pulled?

by lot number

When drug recalls are issued, lot numbers affected will be reported in the drug recall. Pharmacy staff should immediately pull affected stock from the drug inventory.

What phase in drug development determines the appropriate dose with regard to safety and toxicity?

Phase I

Phase I determines the appropriate dose with regard to safety and toxicity. Phase II is performed in 100 to 300 patients who have the disease or condition to be treated. Phase III conducted in larger (several hundred to several thousand) patients in groups that the medication is ultimately intended. A comparison is between new treatment and the standard therapy or placebo. The medication is used in the manner in which it will be used after approval.

What type of agreement is made between a pharmacy and a wholesaler in which the pharmacy agrees to purchase the majority of its product from that wholesaler?

Prime vendor agreement

A prime vendor agreement is established between a pharmacy and wholesaler. A purchase order is a form that is used to order drugs and supplies from a wholesaler. Information found on a purchase order includes the following: name and address of the institution, shipping address, date the order was placed, vendor’s name and address, the purchase order number (a tracking number used to identify a purchase order), the ordering department’s name and location, the expected date of delivery, shipping terms, account name or billing designation, description of items ordered, quantity of items ordered, unit price, extended price, total price of the order, and buyer’s name and phone number.

If a drug has no specific storage requirements listed, at what temperature should it be kept?

68 to 77 degrees F

When there are no storage requirements listed, a drug should be kept at room temperature, which is 68 to 77 degrees F. Not all drugs can be kept in a refrigerator due to stability issues.

Which drug class recall involves a reasonable probability the drug will cause serious adverse health consequences or death?

Class 1 Recall

Class 1 Recall is the most serious of the drug recalls and the one with the most probability of causing harm to a patient.