The iPLEDGE program is designed to mitigate the risks associated with taking:

Isotretinoin is a medication primarily used to treat cystic acne. Common brands include Absorica, Accutane, Amnesteem, Claravis, Epuris, Isotretinoin, and Roaccutane. iPLEDGE is a mandatory distribution program that is intended to prevent the use of isotretinoin during pregnancy, due to the high risk of birth defects.